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KMID : 0606320030190010009
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Journal of Phamacetical Sciences Sookmyung Women s University
2003 Volume.19 No. 1 p.9 ~ p.15
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Effect of Selenium on Natural Killer Cell Activity in Mice
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Choi Ji-Sun
Pyo Myoung-Yun
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Abstract
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Effect of Selenium (Se) on natural killer (NK) cell activity of spleen in mice was investigated. Se 1ppm or 3ppm was orally administered to ICR mice in drinking water for 18 days. Cyclophosphamide (CY) was injected I.p. to mice with a single dose of 10 mg/kg b.w. on the last day of Se-administration. Spleen cells were obtained 24h after CY-injection and used as effector cells. NK cell cytotoxicity (%) was assessed in a 4h 51Cr-release assay against YAC-1 target cells. The treatment of Se alone significantly increased NK cell cytotokicity at low dose (1ppm), but decreased at high dose (3ppm) when compared with control group. The NK cell activity (LU30) was significantly enhanced in Se (1ppm) plus CY, but inhibited in Se (3ppm) plus CY when compared with the treatment of CY alone.
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KEYWORD
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